Dr Jeremy Grimshaw received a MBChB (MD equivalent) from the University of Edinburgh, UK. He trained as a family physician prior to undertaking a PhD in health services research at the University of Aberdeen. He moved to Canada in 2002. His research focuses on the evaluation of interventions to disseminate and implement evidence-based practice. Dr. Grimshaw is the Director, Clinical Epidemiology Program, Ottawa Hosptial Research Institute, Director, Centre for Best Practices, Institute of Population Health, University of Ottawa, Director, Canadian Cochrane Network and Centre, Tier 1 Canada Research Chair in Health Knowledge Transfer and Uptake, and is a Full Professor in the Department of Medicine, University of Ottawa as well as having a cross-appointment with the Faculty of Medicine's Department of Family Medicine. He also spearheads the Knowledge Translation Canada (KT CANADA), a network of KT leading National and International interdisciplinary researchers, across six university settings, local hospitals, community agencies, and the Canadian Institutes of Health Research.
Dr. Jamie Brehaut is a Scientist with the Ottawa Health Research Institute, Assistant Professor in the Department of Epidemiology and Community Medicine at the University of Ottawa, Associate Director of the Ottawa Patient Decision Support Laboratory, and a CIHR New Investigator in the area of Knowledge Translation. Dr. Brehaut holds a PhD in Cognitive Psychology from McMaster University. Trained in issues of human memory, attention, and cognition, Dr. Brehaut also has expertise in psychological theory, knowledge translation, judgement and decision making, decision support, and computer usability techniques.
The overall aim of my research programme in Human Genome Epidemiology has been the application and further development of epidemiologic methods in a multidisciplinary context to the translation of gene discoveries into actions to improve health. The programme has five specific areas:
- methodological work in pursuit of the "road map" for human genome epidemiology;
- investigation of the effects of multiple genes operating in pathways in (a) aetiology (b) response to therapeutic and preventive interventions;
- on the basis of (2), development and evaluation of tests for variants of multiple genes operating in pathways;
- family history - investigation of (a) familial risk; (b) the extent to which this is accounted for by variants of multiple genes thought to influence risk in the general population; (c) use of information on familial risk in stratifying public health interventions;
- evaluation of applications of genomic and related technologies in public health.
The areas in which there is greatest KT emphasis are 1, 4, and 5.
The "road map" (area 1) for understanding the role of genetic variation in human health and how to use evolving knowledge to improve health and prevent disease was developed in response to concerns about non-replication and methodological issues in genetic association studies. Examples of activities include
- STREGA (STrengthening the REporting of Genetic Association studies)
- investigation of the relationship between aspects of the methods used to investigate genetic associations and the direction and magnitude of the results obtained); this work will also serve as a baseline to assess the effect of the STREGA guideline;
- developing harmonization of methods across studies. This is being taken forward through the Public Population Project in Genomics (P3G)
- developing methods for synthesis and meta-analysis of genetic association data, and for "field synopses" with a view to capturing and appraising the state of evolving evidence across entire fields of study.
With regard to family history (area 4), we are investigating issues related to the clinical utility of ascertaining family history of chronic diseases in primary care, and in the screening context.
Evaluation of applications of genomic and related technologies in public health (area 5) includes assessment of potential value of HPV testing in triage of women with low-grade cervical cytological abnormalities, and issues relating to the expansion of newborn screening.
Dr. David Moher is a Senior Scientist with the Clinical Epidemiology Program, Ottawa Health Research Institute and an Associate Professor, Department of Epidemiology and Community Medicine at the University of Ottawa. Dr. Moher is also known around the world for his leadership in developing guidelines for reporting health research, including the internationally-adopted CONSORT guidance for randomized trials, and the PRISMA statement for reporting systematic reviews. He is interested in developing strategies to improve the uptake of reporting guidelines in health care journals.
Dr. O'Connor is a Professor at the University of Ottawa (School of Nursing and Department of Epidemiology & Community Medicine) and a Senior Scientist at the Ottawa Hospital Research Institute Clinical Epidemiology Program.
The goal of Dr. O'Connor's research is to improve: a) the decision making of people facing tough health care choices; and b) the support provided by health professionals who counsel them. Her contributions include: a conceptual framework for managing decisional conflict; over 30 patient decision aids; a widely used evaluation measure of decisional conflict; the first systematic review of trials of patient decision aids, and several knowledge translation interventions for implementing patient decision support.
Dr. O'Connor has been influential in developing patient decision aids methods, systematic reviews, standards, and training. She has developed international standards and a global inventory of evaluated patient decision aids. Since 2004, annual access to the PtDA website is over 1 million hits, 300,000 page views, 150,000 downloads and 40,000 visitors. KT Canada funding maintains this key global resource and expands the toolkit to include an online autotutorial on the development and evaluation of PtDAs, a patient reference report template which can be used in electronic health records after use of PtDAs, and training modules for clinicians to interpret the preference reports and finalize decision making with patients.
Internationally, Dr. O'Connor has projects in the U.S, U.K, and Chile. She leads the International Cochrane Collaboration team that summarizes trials of patient decision aids (over 50) and maintains a global inventory of evaluated patient decisions aids (over 500). Dr. O'Connor co-leads a 14 country international consensus process on standards for developing and evaluating patient decision aids (IPDAS).
She is a Fellow of the Canadian Academy of Health Sciences (2005) and has been recognized with awards such as the Society for Medical Decision Making's John M. Eisenberg Award for Exemplary Leadership in the Practical Application of Medical Decision Making Research (2004), the University of Ottawa's Excellence in Research Award (2005), and Ottawa Life Sciences Council's Health Innovation Award (2006).
Dr. Stacey is an Associate Professor in the School of Nursing at the University of Ottawa and Director of the Patient Decision Aid Research Group at the Ottawa Hospital Research Institute. Her research program is focused on understanding, measuring, and evaluating the effectiveness of knowledge translation interventions to facilitate decision making of patients and their practitioners. Her expertise includes: patient decision aid development, evaluation, and appraisal; decision coaching; and implementation of decision support into clinical practice and curriculum. She leads the Cochrane Collaboration systematic review of patient decision aids, is a member of the Steering Committee for the International Patient Decision Aids Standards (IPDAS) Collaboration, and is a co-investigator for the Cochrane Collaboration systematic review of interventions for improving the adoption of shared decision making by healthcare professionals.
Dr Ian Stiell is Professor and Chair, Department of Emergency Medicine, University of Ottawa; Distinguished Professor and University Health Research Chair, University of Ottawa; and Senior Scientist, Ottawa Hospital Research Institute. He is internationally recognized for his research in emergency medicine with a focus on the development of clinical decision rules and the conduct of clinical trials involving acutely ill and injured patients treated by prehospital services and in emergency departments. He is best known for the development of the Ottawa Ankle Rules and Canadian C-Spine Rule, and as the principal investigator for the landmark OPALS Studies for prehospital care. Dr Stiell is the Principal Investigator for 1of 2 Canadian sites in the Resuscitation Outcomes Consortium (ROC) which is funded by CIHR, NIH, HSFC, AHA, and National Defence Canada. Dr. Stiell is a Member of the Institute of Medicine of the U.S. National Academies of Science.
Monica Taljaard, Ph.D. is a Scientist with the Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Assistant Professor, Department of Epidemiology and Community Medicine at the University of Ottawa. As a biostatistician, her KT research interests relate to the design and analysis of cluster randomized trials, as well as ethical issues in cluster randomized trials.
Dr. Peter Tugwell is Professor of Medicine, and Epidemiology & Community Medicine at the University of Ottawa and is a practicing rheumatologist at the Ottawa Hospital, Ottawa, Canada. In 2001, he took the post of Director for the Centre for Global Health under the Institute of Population Health, University of Ottawa and was awarded a Canada Research Chair in Health Equity. Since 2002 he accepted the position of North American editor of the Journal of Clinical Epidemiology.
He was Chair of the Department of Clinical Epidemiology and Biostatistics for 10 years 1979-1989 at McMaster University. He was then Chair of the Department of Medicine at the University of Ottawa and the Ottawa Hospital for 10 years 1991-2001.
Dr. Tugwell was Founding Director of the International Clinical Epidemiology Network Training Centre at McMaster University [1982-91] and is Past Chair of the Epidemiology Committee of the International League of Associations for Rheumatology [1989-97] and of the Canadian Association of Professors of Medicine [2000-2001]. He is a Fellow of the Royal College of Physicians of Canada, the American College of Physicians, as well as the American College of Rheumatology. Dr. Tugwell is co-director of a WHO Collaborating Centre for Knowledge Translation and Health Technology Assessment in Health Equity as well as a member of the Organizing Committee of OMERACT (Outcome Measures in Rheumatology Clinical Trials). Dr. Tugwell is Coordinating Editor of the Cochrane Musculoskeletal Review Group and the Cochrane/Campbell Health Equity Field. Dr. Tugwell served as Councilor of the newly formed Canadian Academy of Health Sciences.
Dr. Tugwell's publication record includes over 400 journal articles, monographs, and book chapters. Many of these have been in the area of rheumatology, focusing on the assessment of therapeutic interventions and mechanisms of disease. Dr. Tugwell's research interests also extend to developing and evaluating strategies for assessing quality of life and utilities, the evaluation and development of educational strategies in the teaching of medicine, research into the disadvantaged, global health, knowledge translation, decision support and consumer participation in research and health care.
I am currently an Assistant Professor in the Department of Emergency Medicine, University of Ottawa, and an Scientist of the Clinical Epidemiology Unit, Ottawa Hospital Research Institute. I recently completed a research fellowship and a Master of Science in Epidemiology under the supervision of Drs. George Wells, and Ian Stiell, a CIHR Distinguished Investigator. My master's thesis on Cardiopulmonary Resuscitation - Out-of-hospital Cardiac Arrest was awarded first prize by the Department of Epidemiology, Faculty of Medicine, University of Ottawa. My thesis presentation subsequently received a Gold Medal Award at the National CIHR poster competition held in Winnipeg, 2003. I am a member of the most active Emergency Medicine Research Team in Canada, I sit on several national and regional committees pertaining to Emergency Medicine research, and I am an Associate Editor for the Canadian Journal of Emergency Medicine. My major research initiatives have been in two main areas within the field of emergency health services: a) cardiac arrest resuscitation, and b) traumatology.
Canada Research Chair in Thromboembolic Disease
Professor, Department of Medicine
Professor, Department of Epidemiology and Community Medicine,
University of Ottawa
Chief / Chair Department of Medicine, The Ottawa Hospital & University of Ottawa
Director of Clinical Research, The Ottawa Hospital
Associate Director, Clinical Research, Ottawa Health Research Institute
Deputy Head of Research, Dept of Medicine, The Ottawa Hospital
- MD - Magna cum laude (University of Ottawa, 1984)
- FRCP(C) Internal Medicine (University of Ottawa, 1990)
- FRCP(C) Hematology (McMaster University, 1991)
- MSc Clinical Epidemiology (McMaster University, 1994)
Dr. Wells is Professor and Chair / Chair of the Department of Medicine at the University of Ottawa and The Ottawa Hospital. He is a Canada Research Chair and a senior scientist in the Ottawa Health Research Institute. He has a clinical practice in venous thromboembolic diseases and performs both laboratory and clinical trials research in the area of venous thromboembolism. Dr. Wells' particular interests have been in the area of improving diagnosis in patients with suspected DVT or pulmonary embolism and novel ways of treating patients. Economic issues associated with diagnostic and treatment issues have also been an interest as well as meta-analytic techniques for determining efficiencies of treatments that have not been subjected to large-scale clinical trials. More recently, he has been looking at risks associated with thrombotic disorders and an inherited predisposition towards thrombosis (thrombophilia). He has established new paradigms in diagnosis and treatment and new paradigms in the approach to evaluating the risks of thrombosis in the post-operative period.