Dysthymia: Antidepressants are effective
Clinical Bottom Line
Antidepressants are effective in the treatment of dysthymia.
Lima M, Moncrieff J. Drugs versus placebo for dysthymia (Cochrane Review). In: The Cochrane Library, Issue 1, 1999. Oxford: Update Software.
In an adult with dysthymia, are antidepressants effective in lifting mood?
'dysthymia' in The Cochrane Library
Systematic review of trials of any antidepressant versus placebo. Extensive search for literature. Rigorous appraisal of validity of individual studies.
- 15 RCTs, including trials of TCAs, SSRIs, MAOIs, and other drugs.
- Outcome: no treatment response
|CER||EER||ARR (95% CIs)||NNT (95% CIs)|
|TCAs||0.68||0.45||0.23 (0.31, 0.16)||4.3 (3.3, 6.5)|
|MAOIs||0.78||0.45||0.33 (0.22, 0.43)||3.1 (2.3, 4.5)|
|SSRIs||0.61||0.39||0.22 (0.15, 0.28)||4.7 (3.5, 6.9)|