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Centre for Evidence-
Based Medicine

Stroke-risk of seizure

Clinical Bottom Line

Acute Cholecystitis - Lap chole may be as safe as open chole


Burn J, Dennis M, Bamford J et al. Epileptic seizures after a first stroke: the Oxfordshire community stroke project. BMJ 1997;315:1582-7

Clinical Question

In a patient with stroke, what is the risk of seizure at one year?

Search Terms

"stroke" and "seizure" in Medline

The Study

  • 675 pts registered in a community-based stroke registry after their first stroke
  • The Outcome: seizure
  • Well-defined sample at uniform (early) stage of illness..?, yes;
  • Follow-up long enough..?, yes;
  • Follow-up complete..?, yes;
  • Blind and objective outcome criteria..?, no;
  • Adjustment for other prognostic factors..?, no;
  • Validation in an independent "test-set" of patients..?, no

The Evidence

Prognostic Factor Outcome Time Measure Likelihood Ratio
cerebral infarction seizure 1 year 4.2% 2.2 to 6.2%
primary intracerebral haemorrhage seizure 1 year 20% 1.5 to 38.3%
subarachnoid haemorrhage seizure 1 year 22% 2.6 to 41.8%
any stroke seizure 1 year 5.7% 3.5 to 7.9%

Appraised By

Straus, 1998

Expiry Date