Migraine - Riboflavin is effective prophylaxis
Clinical Bottom Line
Treating two patients with migraine with 400mg riboflavin per day will resul in one of them having a 50% reduction in migraine frequency, though with no effect on severity.
Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomised controlled trial. Neurology. 1998; 50: 466-70.
Is riboflavin effective in preventing migraine?
migraine AND riboflavin
- Double-blinded concealed randomised controlled trial with intention-to-treat.
- The Study Patients: recurrent migraines
- Control group (N = 27; 27 analysed): placebo
- Experimental group (N = 28; 28 analysed): riboflavin 400mg daily
|Outcome||Time to Outcome||CER||EER||RRR||ARR||NNT|
|Non-responder (<50% reduction)||0.85||0.41||52%||0.440||2|
|95% Confidence Intervals||25% to 78%||0.213 to 0.667||2 to 5|
We have two caveats:
- This is the only study, and has modest numbers (55).
- The effect appeared to take 2-3 months to build up; patients need to be warned it will not necessarily work immediately.
Paul Glasziou, Social & Preventive Medicine, Herston Rd, Herston QLD 4006 AUSTRALIA
Thursday, January 21, 1999
Kill or Update By: 1/12/2000 (check for new trials)