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Centre for Evidence-
Based Medicine

Therapy: Clinical Scenario

A middle aged woman presented with exacerbation of her usual pattern of migraine. She asked specifically about whether riboflavin might help as she had heard from a friend that it helped prevent migraine. Together you formulate the question, in patients with frequent migraines , is riboflavin effective in the reduction of migraine frequency or severity?

Searching terms and evidence source:
Since this is a question of intervention, a randomised trial would be ideal. The most comprehensive and easy to check source is the Controlled Clinical Trials Registry (CCTR) in the Cochrane Library. I used the terms "migraine and riboflavin" (no methodological filters are needed as only list controlled trials).

This gives 2 hits, one of which is: Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomised controlled trial. Neurology. 1998; 50: 466-70.

Read the article and decide:

  1. IsIs the evidence from this trial valid?
  2. If valid, is this evidence important?
  3. If valid and important, can you apply this evidence in caring for your patient?

Continue to completed worksheet