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Centre for Evidence-
Based Medicine

Harm: Clinical Scenario

A 50 year old man asked for a repeat prescription of sotalol which he had been taking for several years for his extrasystoles. I had not previously seen him, and was cautious because of the number of antiarrhythmics which had proarrhythmic properties. I formulated the question, in patients with extrasystoles does sotalol increase the risk of sudden cardiac death?

Searching terms and evidence source: sotalol AND (mortality OR death*) - search done in the Cochrane Controlled Trials Registry

Read the article and decide:

  1. Is the evidence from this study valid?
  2. If valid, is this evidence important?
  3. If valid and important, can you apply this evidence in caring for your patient?

Continue to completed worksheet