Steroid Induced - Osteoporosis Bisphosphonates Improves Bone Mineral Desity
Clinical Bottom Line
Bisphosphonates improve bone mineral density in patients with steroid induced osteoporosis.
Homik J, Cranney A, Shea B, et al. Bisphosphonates for steroid induced osteoporosis. CDSR 1999;issue 1.
In a patient with steroid induced osteoporosis, does treatment with bisphosphonates reduce bone pain, fracture rate and improve bone mineral density?
"osteoporosis" and "steroids" in Cochrane Library
Systematic review of controlled trials that studied the effect of bisphosphonates on steroid induced osteoporosis. Bone mineral density was taken as the only outcome measure.
|Outcome||ARR (weighted)||NNT (95% CI)|
|Bone mineral density increase||.043||23 (17 to 37)|
The authors state that there is a relationship between BMD, and pain and fracture rates, but emphasise that the results do not permit us to draw conclusions about the efficacy of bisphosphonates in preventing fractures in steroid induced osteoporosis.
W Rosenberg, 1999