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Centre for Evidence-
Based Medicine

Harm - Sotalol

You see a 50 year old man who asks for a repeat prescription of sotalol which he has been taking for extrasystoles for several years. He has a remote history of an MI. You haven't seen him previously and are concerned about the proarrhythmic properties of sotalol given what is known about other antiarrhythmics.

What clinical questions could you ask?

Patient or Problem:
Intervention:
Comparison Intervention:
Outcome:
Your Question:

Compare your answer to the question we formulated

Patient or Problem:
Man with extrasystoles
Intervention:
Sotalol
Comparison Intervention:
Placebo
Outcome:
Death
Question:
In a man with extrasystoles and a remote history of MI, does treatment with sotalol increase his risk of death?