In children with mild to moderate croup, does nebulised budesonide decrease the risk of hospital admission compared with placebo? Klassen, T.P. Feldman, M.E. Watters, L.K. et al. Nebulized budesonide for children with mild to moderate croup. NEJM 1994; 331(5):285-289.
In children with hyperactivity, does any form of dietary modification improve behaviour? Schmidt MH, Mocks P, Lay B, Eisert HG, Fojkar R, Fritz Sigmund D, Marcus A, Musaeus B. Does oligoantigenic diet influence hyperactive/conduct-disordered children-a controlled trial. Eur Child Adolesc Psychiatry 1997;6:88-95.
Critical Care Medicine
In a critically ill patient, will restrictive blood transfusion practices be equivalent to liberal transfusion practices? A multicenter, randomized, controlled clinical of transfusion requirements in Critical Care. NEJM 1999;340:409-17.
EBM in Developing Countries
Among Filipino patients with suspected MI, will administration of streptokinase decrease in-hospital mortality? ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988; ii:349-360.
Gastroenterology and Hepatology
In a patient with nonulcer dyspepsia and helicobacter pylori infection, will helicobacter eradication therapy result in a reduction in symptoms of dyspepsia?McColl K et al. Symptomatic benefit from eradicating helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med 1998;339:1869-74.
In 35 year old man who is HCV RNA positive does treatment with interferon + ribavirin, compared to interferon alone, or no treatment, offer a significant chance of viral clearance? Poynard T, Marcellin P, Lee SS, et al. Interferon a2b and ribavirin increased the loss of HCV RNA in chronic hepatitis C. Lancet 1998;352:1426-32.
In patients with frequent migraines, is riboflavin effective in the reduction of migraine frequency or severity? Schoenen J, Jacquy J, and Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomised controlled trial. Neurology, 1998; 50: 466-470.
In patients with acute cholecystectomy, what is the complication rate of laparascopic cholecystectomy versus open cholecystectomy? Kiviluoto T et al. Randomised trial of laparoscopic versus open cholecystectomy for acute and gangrenous cholecystitis. Lancet 1998;351:321-5.
In patients with isolated systolic hypertension, do diuretics decrease the risk of stroke and death? SHEP co-operative research group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the systolic hypertension in the elderly program. (SHEP). JAMA 1991;265:3255-64.
In an elderly patient who lives at home, does a comprehensive geriatric assessment decrease the risk of nursing home admission and improve functional status? Stuck AE, Aronow HU, Steiner A et al. A trial of annual in-home comprehensive geriatric assessments for elderly people living in the community. NEJM 1995;333:1184-9.
In a mentally ill homeless person, does a "critical time" intervention prevent extended homelessness? Susser E, Valencia E, Conover S, et al. Preventing recurrent homelessness among mentally ill men: a 'critical time' intervention after discharge from a shelter. Am J Public Health 1997 Feb; 87: 256-62.
In a term infant with hypoxic respiratory failure, does the use of inhaled nitric oxide decrease the need for ECMO? Ehrenkranz R.A. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997; 336(9): 597-604.
In school age children with colds, are zinc lozenges safe and effective for relief of cold symptoms? Macknin ML, Piedmonte M, Calendine C, Janosky J, Wald, E. Zinc gluconate lozenges for treating the common cold in children. A randomized controlled trial. JAMA 1998;279:1962-7.
Is prophylactic physiotherapy for patients undergoing upper abdominal surgery effective in preventing post-operative pulmonary complications? Fagevik Olsen M, Hahn I, Nordgren S, Lonroth H, Lundholm K. Randomized controlled trial of prophylactic chest physiotherapy in major abdominal surgery. British Journal of Surgery 1997;84:1535-1538.
Should rivastigmine be considered in patients with Alzheimer's for improving quality of life and reducing carers' costs? Rosler M, Anand R, Cicin-Sain A, Gauthier S et al.Efficacy and safety of rivastigmine in patients with Alzheimer's Disease: international randomised controlled trial.BMJ 1999;318:633-40.