In young infants with projectile vomiting and no palpable pyloric tumour, what is the probability of pyloric stenosis with a negative or a positive ultrasound of the pylorus? Neilson D, Hollman AS. The ultrasonic diagnosis of infantile hypertrophic pyloric stenosis: technique and accuracy. Clinical Radiology 1994;49:246-7.
Critical Care Medicine
In mechanically ventilated patients, can the respiratory rate to tidal volume ratio be used to predict successful extubation? Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med 1991; 324:1445-50.
EBM in Developing Countries
In a patient with suspected typhoid fever, what is the accuracy of the Typhidot test for making the diagnosis? Phil J of Med - Infectious Dis 1997; 26:61-63.
Gastroenterology and Hepatology
In a patient with anaemia can a low serum ferritin be used to diagnose iron deficiency? Guyatt GH, Patterson CH, Ali M. Diagnosis of iron-deficiency anemia in the elderly. Am J Med 1990; 88:205-9.
What is the accuracy of microtympanometry for the diagnosis of hearing loss from a middle ear effusion in young children? Holty I, Forster DP. Evaluation of pure tone audiometry and impedance screening in infant schoolchildren. J Epidemiol Community Health 1992; 46: 21-25.
In a patient with a history of breast cancer and breast conserving surgery what is the best method for detecting local recurrence? Drew PJ et al. Routine screening for local recurrence following breast-conserving therapy for cancer with dynamic contrast-enhanced magnetic resonance imaging of the breast. Ann Surg Onc 1998;5:265-70.
In an elderly woman with hypochromic, microcytic anaemia, can a low ferritin diagnose iron deficiency anaemia? Guyatt GH, Patterson C, Ali M, Singer J, Levine M, Turpie I, Meyer R Diagnosis of iron-deficiency anemia in the elderly. Am J Med 1990; 88: 205-9
In female college students, are there any screening tests that reliably detect those students that have eating disorders? Mintz et al. Questionnaire for eating disorder: reliability and validity of operationalising DSM-IV criteria into a self-report format. Journal of Counseling Psychology 44:63-79.
In preterm infants, what is the accuracy of the clinical examination as a diagnostic test for patent ductus arteriosus (PDA) with left to right shunting? Davis P., Turner-Gomes S., Cunningham K., et al. Precision and Accuracy of Clinical and Radiological Signs in Premature Infants at Risk of Patent Ductus Arteriosus. Arch Pediatr Adolesc Med. 1995; 149: 1136-1141.
In patients with suspected depression what is the accuracy of a 2-question case-finding instrument for depression compared with 6 previously validated instruments? Whooley MA, Avins, AL, Miranda J, Browner WS. Case-finding instruments for depression: Two questions are as good as many. J. Gen Intern Med 1997;12:439-45.
Is your clinical diagnosis of internal derangement correct when presented with a patient with the following clinical [history of locking, preauricular pain, reproducible and reciprocal click, reduced mouth opening (35 mm), local muscle tenderness, reduced joint play] and tomography findings (diminished anterior translation of both condyles, no osseous changes)? Schiffman EL, Anderson GC, Fricton JR, Burton K, Schellhas KP. Diagnostic criteria for intrarticular temporomandibular disorders. Community Dent Oral Epidemiol 1989; 17:252-257.
In patients with a skin lesion, how accurate are general physicians at diagnosing skin cancer? Whited JD, Hall RP, Simel DL, Horner RD. Primary care clinicians' performance for detecting actinic keratoses and skin cancer. Arch Intern Med. 1997;157:985-90.