We are currently updating our website, and will have our new version online soon. Please check back later this fall.

Mailing List

Subscribe to the KT Canada mailing list

Login

Welcome

Signup

Once you have signed up, you will receive a confirmation email with your username and password. To activate your account, follow the instructions in the email.

 

Centre for Evidence-
Based Medicine

Example NNTs - Endocrinology

Condition or Disorder Intervention vs. Control Outcome Follow-up Duration Event Rates % NNT (95% CI)
CER EER
Graves Hyperthyroidism1 Radioiodine and prednisone vs. radioiodine therapy Development and improvement of opthalmopathy 1 year 15 0 7 (5 to 11)
Type 2 diabetes mellitus in overweight patients2 Radioiodine and prednisone vs. radioiodine therapy Diabetes related end point 10 years 39 29 10 (6 to 29)
Deaths from diabetes 13 8> 19 (10 to 138)
All cause mortality 22 15 14 (8 to 67)
MI 18 11 16 (9 to 78)
Diabetic men with erectile dysfunction3 Sildenafil vs. placebo Improved erections 12 weeks 10.2 56.5 3 (2 to 3)
"Insulin requiring" diabetes4 Regular telephone contact with a diabetes nurse educator for advice about adjustment of insulin therapy vs. regular clinic visits and usual contact with the endocrinologist for insulin adjustment Mean HbAlc level and proportion of patients who achieved a reduction in HbAlc level ≥ 10% 6 months 35 87 2 (1 to 4)

References

  1. N Engl J Med 1998 Jan 8;338(2):73-8
  2. Lancet 1998 Sep 12;352(9131):854-65
  3. JAMA 1999 Feb 3;281(5):421-6
  4. CMAJ. 19 Oct 1999; 161: 959-62